The Cabinet is composed as follows:
- President of the Government of Spain, Pedro Sánchez Pérez-Castejón
- First Vice-President of the Government of Spain and Minister for the Economy and Digital Transformation, Nadia Calviño Santamaría
- Second Vice-President of the Government of Spain and Minister for Work and Social Economy, Yolanda Díaz Pérez
- Third Vice-President of the Government of Spain and Minister for Ecological Transition and Demographic Challenge, Teresa Ribera Rodríguez
- Minister for Foreign Affairs, European Union and Cooperation, José Manuel Albares Bueno
- Minister for Justice, Pilar Llop Cuenca
- Minister for Defence, Margarita Robles Fernández
- Minister for Finance and Public Function, María Jesús Montero Cuadrado
- Minister for Home Affairs, Fernando Grande-Marlaska Gómez
- Minister for Transport, Mobility and Urban Agenda, Raquel Sánchez Jiménez
- Minister for Education and Vocational Training, Pilar Alegría Continente
- Minister for Industry, Trade and Tourism, Reyes Maroto Illera
- Minister for Agriculture, Fisheries and Food, Luis Planas Puchades
- Minister for the Presidency, Parliamentary Relations and Democratic Memory, Félix Bolaños García
- Minister for Territorial Policy and Government Spokesperson, Isabel Rodríguez García
- Minister for Culture and Sport, Miquel Iceta Llorens
- Minister for Health, Carolina Darias San Sebastián
- Minister for Social Rights and 2030 Agenda, Ione Belarra Urteaga
- Minister for Science and Innovation, Diana Morant Ripoll
- Minister for Equality, Irene Montero Gil
- Minister for Consumer Affairs, Alberto Garzón Espinosa
- Minister for Inclusion, Social Security and Migration, José Luis Escrivá Belmonte
- Minister for Universities, Joan Subirats Humet